Invitrogen™ TFF2 Monoclonal Antibody (4G7C3)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA531930

Catalog No. PIMA531930

Description

MA5-31930 has been tested in indirect ELISA.

Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing and protection of the gastrointestinal epithelia. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. SP (spasmolytic polypeptide), also designated Trefoil factor 2 (TFF2) precursor, is a trefoil protein that functions to inhibit gastrointestinal motility and gastric acid secretion. SP may also act as a structural component of the gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. A downregulation of SP expression is associated with primary gastric cancer, and a progressive loss of this protein is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway.

Specifications

• Antigen: TFF2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: Q03403
• Gene Symbols: Tff2
• Immunogen: Purified recombinant fragment of human TFF2 (AA: 20-125) expressed in E. coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Western Blot
• Clone: 4G7C3
• Conjugate: Unconjugated
• Gene: Tff2
• Gene Alias: mSP; pancreatic spasmolytic polypeptide; PSP; SML1; SP; spasmolysin; Spasmolytic polypeptide; spasmolytic protein 1; Tff2; Trefoil factor 2; trefoil factor 2 (spasmolytic protein 1)
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 7032
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid