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Invitrogen™ TFF2 Polyclonal Antibody
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Catalog No. PA550276
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100 μL
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PA550276 100 μL
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Catalog No. PA550276 Supplier Invitrogen™ Supplier No. PA550276
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total SP / TFF2 protein.

Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing and protection of the gastrointestinal epithelia. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. SP (spasmolytic polypeptide), also designated Trefoil factor 2 (TFF2) precursor, is a trefoil protein that functions to inhibit gastrointestinal motility and gastric acid secretion. SP may also act as a structural component of the gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. A downregulation of SP expression is associated with primary gastric cancer, and a progressive loss of this protein is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TFF2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Tff2
Gene Accession No. Q03403
Gene Alias mSP; pancreatic spasmolytic polypeptide; PSP; SML1; SP; spasmolysin; Spasmolytic polypeptide; spasmolytic protein 1; Tff2; Trefoil factor 2; trefoil factor 2 (spasmolytic protein 1)
Gene Symbols Tff2
Host Species Rabbit
Immunogen Fusion protein corresponding to a region derived from internal residues of human trefoil factor 2.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7032
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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