Invitrogen™ TGF beta-1,2,3 Monoclonal Antibody (1D11.16.8), Functional Grade, eBioscience™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-112-3008	Invitrogen™ 16924385	500 μg

Description

Description: The monoclonal antibody 1D11.16.8 recognizes human, mouse, rat, hamster, canine and non-human primate Transforming Growth Factor (TGF) beta 1, 2 and 3. TGF beta is a pleiotropic cytokine that exists as five isoforms (TGF beta 1-5) that share 70-80% homology with each other. However, these isoforms are not homologous to TGF alpha. TGF beta 1 is highly conserved between human, murine, simian, bovine, porcine, and chicken proteins. TGF beta 1 is the most abundant isoform and is ubiquitously expressed by a variety of cell types, including platelets, macrophages, lymphocytes, endothelial cells, chondrocytes, and leukemic cells. However, the other isoforms exhibit a more restricted expression pattern. TGF beta 1 is synthesized as a long precursor polypeptide, which is cleaved to yield the mature protein and the Latency Associated Peptide (LAP). LAP and mature TGF beta 1 remain non-covalently associated during secretion, forming homodimers known as the Small Latent Complex (SLC). Secretion can be induced by steroids, retinoids, EGF, NGF, vitamin D3, and IL-1. The bioactivity of mature TGF beta 1 is dependent on its release from LAP by conformational changes and proteolytic processing. Its activities include inhibition of cell growth in epithelial cells, endothelial cells, fibroblasts, neurons, lymphoid cells, and other hematopoietic cell types. TGF beta 1 also inhibits the proliferation of T and NK cells, downregulates the activities of activated macrophages, and blo...

TGF-beta1, -2, and -3 are a closely related group of proteins (70-80% sequence homology) that are produced by many cell types and function as growth and differentiation factors. The active forms of TGF-beta1, -2, and -3 are disulfide-linked homodimers.

Specifications

• Antigen: TGF beta-1,2,3
• Concentration: 1 mg/mL
• Applications: Functional Assay, Immunohistochemistry (Paraffin), Neutralization
• Conjugate: Functional Grade
• Host Species: Mouse
• Regulatory Status: RUO
• Formulation: PBS with no preservative; pH 7.2
• Gene Accession No.: P01137, P04202, P10600, P17125, P17246, P27090, P54831, P61812, Q07257, Q07258
• Gene ID (Entrez): 100756831, 100773359, 100774918, 21803, 21808, 21809, 25717, 403998, 488596, 490796, 574135, 59086, 703239, 7040, 7042, 7043, 707540, 81809
• Primary or Secondary: Primary
• Purification Method: Affinity chromatography

• Clone: 1D11.16.8
• Content And Storage: 4°C
• Classification: Monoclonal
• Form: Liquid
• Isotype: IgG1
• Target Species: Human, Mouse, Rat, Canine, Monkey, Hamster, Rhesus Macaque
• Gene: TGFB3
• Gene Alias: CED; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; tgf beta 1; tgf beta 3; tgf beta1; TGFB; Tgfb1; Tgfb-1; TGFB4; TGFbeta; TGF-beta 1; TGFbeta1; TGF-beta1; TGF-beta-1; TGF-beta4; tissue growth factor-beta4; Transforming growth factor; transforming growth factor beta 1; transforming growth factor beta 4; transforming growth factor beta 4 precursor; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor beta-1 proprotein; transforming growth factor beta-1; transforming growth factor, beta 1; transforming growth factor, beta 1 (Camurati-Engelmann disease); transforming growth factor, beta-1; transforming growth factor-beta 1; transforming growth factor-beta-1 precursor
• Gene Symbols: TGFB1, TGFB2, TGFB3
• Product Type: Antibody