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Invitrogen™ TGF beta-1,2,3 Monoclonal Antibody (eBioTB2F), eBioscience™

Rat Monoclonal Antibody

$141.00 - $419.00

Specifications

Antigen TGF beta-1,2,3
Clone eBioTB2F
Concentration 0.5 mg/mL
Content And Storage 4°C
Applications ELISA
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-139-03
Encompass_Preferred
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Invitrogen™
14994381
50 μg
Each for $141.00
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14-994-385
Encompass_Preferred
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Invitrogen™
14994385
500 μg
Each for $419.00
Only null left
Edge
Add to Cart
 
Description

Description

Description: The eBioTB2F antibody reacts with Transforming Growth Factor-beta (TGF-beta), a pleiotropic cytokine, exists in five isoforms, known as TGF-beta1-5. Homologies between isoforms range from 70-80% but no homology exists to TGF-alpha. TGF-beta1 is ubiquitous and the most abundant form found in lymphoid organs, while other isoforms are expressed in a more restricted distribution. The biologically active state of all isoforms are disulfide-linked homodimers. The heat- and acid- stable monomeric subunits have a length of 112 amino acids. The isoforms of TGF-beta arise by proteolytic cleavage of longer precursors; the isoforms are derived from the carboxyterminal ends of these precursors. Isoforms isolated from different species are evolutionarily closely conserved and have sequence identities on the order of 98%. Mature human, porcine, simian, chicken and bovine TGF-beta1 are identical and differ from mouse TGF-beta1 in a single amino acid. TGF-beta1 is produced in very high levels by platelets. Other cellular sources of TGF-beta1 include macrophages, lymphocytes, endothelial cells, chondrocytes, and leukemic cells. TGF-beta1 secretion can be induced by steroids, retinoids, EGF, NGF, vitamin D3, and IL-1. Activities of TGF-beta1 include inhibition of cell growth for inhibitor for normal and transformed epithelial cells, endothelial cells, fibroblasts, neurons, and lymphoid cells and other hematopoietic cell types. TGF-beta1 inhibits the proliferation of T cells and ...

TGF-beta1, -2, and -3 are a closely related group of proteins (70-80% sequence homology) that are produced by many cell types and function as growth and differentiation factors. The active forms of TGF-beta1, -2, and -3 are disulfide-linked homodimers.
Specifications

Specifications

TGF beta-1,2,3
0.5 mg/mL
ELISA
Unconjugated
Rat
RUO
PBS with 0.09% sodium azide; pH 7.2
P01137, P10600, P61812
7040, 7042, 7043
Primary
Affinity chromatography
eBioTB2F
4°C
Monoclonal
Liquid
IgG2a κ
Human
TGFB3
CED; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; tgf beta 1; tgf beta 3; tgf beta1; TGFB; Tgfb1; Tgfb-1; TGFB4; TGFbeta; TGF-beta 1; TGFbeta1; TGF-beta1; TGF-beta-1; TGF-beta4; tissue growth factor-beta4; Transforming growth factor; transforming growth factor beta 1; transforming growth factor beta 4; transforming growth factor beta 4 precursor; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor beta-1 proprotein; transforming growth factor beta-1; transforming growth factor, beta 1; transforming growth factor, beta 1 (Camurati-Engelmann disease); transforming growth factor, beta-1; transforming growth factor-beta 1; transforming growth factor-beta-1 precursor
TGFB1, TGFB2, TGFB3
Antibody
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SDS
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Documents

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