TGF beta-1 Monoclonal Antibody (2E6), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA121479

Catalog No. PIMA121479

Description

MA1-21479 detects TGF beta in Human samples. MA1-21479 has been successfully used in ELISA and Western Blot procedures. MA1-21479 immunogen corresponds to TGF-beta 1 from human platelets. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.

Specifications

• Antigen: TGF beta-1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Gene: TGFB1
• Gene Alias: CED, DPD1, LAP, TGFB, TGFbeta
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 443417, 7040
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Neutralization, Western Blot
• Clone: 2E6
• Conjugate: Unconjugated
• Gene Accession No.: P01137, P50414
• Gene Symbols: TGFB1
• Immunogen: TGF-beta 1 from human platelets
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Ovine
• Product Type: Antibody
• Isotype: IgG1