Invitrogen™ TGF beta-3 Monoclonal Antibody (C1)

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA541683	Invitrogen™ MA541683	200 μL
PIMA543704	Invitrogen™ MA543704	20 μL

Description

TGF beta-3 Monoclonal Antibody for Western Blot

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.

Specifications

• Antigen: TGF beta-3
• Concentration: 1 mg/mL
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300
• Gene Accession No.: P10600
• Gene ID (Entrez): 7043
• Immunogen: Recombinant protein Transforming Growth Factor Beta 3. The antigen corresponds to amino acid range 24-300 of the target protein.
• Product Type: Antibody

• Clone: C1
• Content And Storage: -20°C
• Classification: Monoclonal
• Form: Liquid
• Isotype: IgG2b κ
• Target Species: Human
• Gene: TGFB3
• Gene Alias: ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3
• Gene Symbols: TGFB3
• Primary or Secondary: Primary
• Purification Method: Protein A/G