Invitrogen™ TGF beta-3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597064

Catalog No. PIPA597064

Description

Immunogen sequence: STCTTLDFGH IKKKRVEAIR GQILSKLRLT SPPEPTVMTH VPYQVLALYN STRELLEEMH GEREEGCTQE NTESEYYAKE IHKFDMIQGL AEHNELAVCP KGITSKVFRF NVSSVEKNRT NLFRAEFRVL RVPNPSSKRN EQRIELFQIL RPDEHIAKQR YIGGKNLPTR GTAEWLSFDV TDTVREWLLR RESNLGLEIS IHCPCHTFQP NGDILENIHE VMEIKFKGVD NEDDHGRGDL GRLKKQKDHH NPHLILMMIP PHRLDNPGQG GQRKKR; Positive Samples: BT-474, K-937, Mouse lung, Mouse skeletal muscle, Mouse heart, Rat lung, Rat heart.

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.

Specifications

• Antigen: TGF beta-3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TGFB3
• Gene Alias: ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21809, 25717, 7043
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.59 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P10600, P17125, Q07258
• Gene Symbols: TGFB3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human TGFB3 (NP_0032301).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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