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Invitrogen™ TGF beta-3 Polyclonal Antibody
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Catalog No. 01674805
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250 μg
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Catalog No. Quantity
01-674-805 250 μg
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Catalog No. 01-674-805 Supplier Invitrogen™ Supplier No. PA112642
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Description

Sheep Polyclonal Antibody

A suggested positive control for this product is extraembryonic membranes from chick embryos.

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
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Specifications

Antigen TGF beta-3
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 0.08% sodium azide
Gene TGFB3
Gene Accession No. P16047
Gene Alias ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3
Gene Symbols TGFB3
Host Species Sheep
Immunogen Recombinant protein corresponding to the extracellular domain of the chicken TGF III receptor.
Purification Method Ammonium sulfate precipitation
Quantity 250 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 396438
Target Species Chicken
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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