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Invitrogen™ TGF beta-3 Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA112642

Catalog No. 01-674-805


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Description

Description

A suggested positive control for this product is extraembryonic membranes from chick embryos.

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TGF beta-3
Polyclonal
PBS with 0.08% sodium azide
P16047
TGFB3
Recombinant protein corresponding to the extracellular domain of the chicken TGF III receptor.
250 μg
Primary
Chicken
Antibody
IgG
Immunohistochemistry, Western Blot, Immunocytochemistry
Unconjugated
TGFB3
ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3
Sheep
Ammonium sulfate precipitation
RUO
396438
-20°C, Avoid Freeze/Thaw Cycles
Liquid
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