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Invitrogen™ TGF beta-3 Polyclonal Antibody
Sheep Polyclonal Antibody
Supplier: Invitrogen™ PA112642
Description
A suggested positive control for this product is extraembryonic membranes from chick embryos.
Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
Specifications
TGF beta-3 | |
Polyclonal | |
PBS with 0.08% sodium azide | |
P16047 | |
TGFB3 | |
Recombinant protein corresponding to the extracellular domain of the chicken TGF III receptor. | |
250 μg | |
Primary | |
Chicken | |
Antibody | |
IgG |
Immunohistochemistry, Western Blot, Immunocytochemistry | |
Unconjugated | |
TGFB3 | |
ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3 | |
Sheep | |
Ammonium sulfate precipitation | |
RUO | |
396438 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
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