Invitrogen™ TGF beta-3 Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA112642

Catalog No. 01-674-805

Description

A suggested positive control for this product is extraembryonic membranes from chick embryos.

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.

Specifications

• Antigen: TGF beta-3
• Classification: Polyclonal
• Formulation: PBS with 0.08% sodium azide
• Gene Accession No.: P16047
• Gene Symbols: TGFB3
• Immunogen: Recombinant protein corresponding to the extracellular domain of the chicken TGF III receptor.
• Quantity: 250 μg
• Primary or Secondary: Primary
• Target Species: Chicken
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Gene: TGFB3
• Gene Alias: ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3
• Host Species: Sheep
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 396438
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid