TGF beta-3 Polyclonal Antibody, Biotin, PeproTech®, Invitrogen™

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
500P317BT25	Pepro Tech Inc 500P317BT25UG	25 μg
500P317BT50	Pepro Tech Inc 500P317BT50UG	50 μg
50-271-8517	LIFE TECHNOLOGIES 500P317BT500UG	500 μg

Description

AA Sequence of recombinant protein: ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human TGF-beta3. Anti-Human TGF-beta3-specific antibody was purified by affinity chromatography and then biotinylated. Western Blot: To detect Human TGF-beta3 by Western Blot analysis, this antibody can be used at a concentration of 0.1-0.2 μg/mL. When used in conjunction with compatible development reagents, the detection limit for Recombinant Human TGF-beta3 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions. 500-P317BT-1MG will be provided as 2 x 500 μg

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.

Specifications

• Antigen: TGF beta-3
• Applications: Western Blot
• Conjugate: Biotin
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: P10600
• Gene ID (Entrez): 7043
• Immunogen: E.coli-derived Recombinant Human TGF-beta3.
• Purification Method: Antigen Affinity Chromatography
• Gene: TGFB3

• Concentration: 0.1-1.0 mg/mL
• Classification: Polyclonal
• Form: Lyophilized
• Regulatory Status: RUO
• Formulation: PBS with no preservative
• Gene Alias: ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3
• Gene Symbols: TGFB3
• Primary or Secondary: Primary
• Content And Storage: -20°C