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Invitrogen™ TGF beta-3 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA585307
Description
Keep as concentrated solution. Predicted reactivity: Mouse (97%), Rat (97%), Pig (87%), Chicken (86%), Rhesus Monkey (100%), Bovine (85%). Positive Control: mouse placenta, human TGFB3-transfected 293T. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
Specifications
TGF beta-3 | |
Polyclonal | |
Unconjugated | |
TGFB3 | |
ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
21809, 7043 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot | |
0.86 mg/mL | |
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 | |
P10600, P17125 | |
TGFB3 | |
Recombinant protein encompassing a sequence within the center region of human TGF-beta-3. | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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