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TGFB1 Mouse anti-Human, Clone: OTI1E12, liquid, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA506585

Encompass_Preferred

Catalog No. 50-167-6677


May include imposed supplier surcharges.
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Description

Description

TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.
Specifications

Specifications

TGFB1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P01137
TGFB1
Full length human recombit protein of human TGFB1 produced in HEK293T cell.
100 μL
Primary
Human
Antibody
IgG2a
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
OTI1E12
Unconjugated
TGFB1
CED, DPD1, LAP, TGFB, TGFbeta
Mouse
Affinity Chromatography
RUO
7040
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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