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TGFB1 Mouse anti-Human, Clone: OTI2B5, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF506584

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.Specifications
TGFB1 | |
Monoclonal | |
Unconjugated | |
TGFB1 | |
CED, DPD1, LAP, TGFB, TGFbeta | |
Mouse | |
Affinity Chromatography | |
RUO | |
7040 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Western Blot | |
OTI2B5 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
P01137 | |
TGFB1 | |
Full length human recombit protein of human TGFB1 produced in HEK293T cell. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2a |
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