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TGFBR1 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA595863
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PIPA595863 100 μL
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Catalog No. PIPA595863 Supplier Thermo Scientific Supplier No. PA595863

Description

Rabbit Polyclonal Antibody

Positive Samples: HeLa, SW480, 22Rv1, mouse brain, rat brain Immunogen sequence: EEDPSLDRPF ISEGTTLKD

TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
TRUSTED_SUSTAINABILITY

Specifications

Antigen TGFBR1
Applications Western Blot
Classification Polyclonal
Concentration 1.14 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene TGFBR1
Gene Accession No. P36897, P80204, Q64729
Gene Alias AAT5, activin A receptor type II-like kinase, 53kDa, activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, ACVRLK4, ALK5, Alk-5, AU017191, ESK2, ESS1, LDS1, LDS1A, LDS2A, MSSE, mutant transforming growth factor beta receptor I, ser, serine/threonine-protein kinase receptor R4, SKR4, TbetaRI, tbetaR-I, tgf beta receptor 1, TGF-beta receptor type I, TGF-beta receptor type-1, TGF-beta type I receptor, TGFBR1, TGFR1, TGFR-1, Transfor, transforming growth factor beta receptor 1, transforming growth factor beta receptor I, transforming growth factor, beta receptor 1, transforming growth factor, beta receptor I, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa), transforming growth factor-beta receptor type I
Gene Symbols TGFBR1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 161-179 of human TGF beta Receptor I (TGFBR1) (NP_004603.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21812, 29591, 7046
Target Species Human, Mouse, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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