TGFBR2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA588247

Catalog No. PIPA588247

Description

Immunogen sequence: TIPPHVQKSV NNDMIVTDNN GAVKFPQLCK FCDVRFSTCD NQKSCMSNCS ITSICEKPQE VCVAVWRKND ENITLETVCH DPKLPYHDFI LEDAASPKCI MKEKKKPGET FFMCSCSSDE CNDNIIFSEE YNTSNPDLLL VIFQVTGISL LPPLGVAISV IIIFYCYRVN RQQKLSSTWE TGKTRKLMEF SEHCAIILED DRSDISSTCA NNINHNTELL PIELDTLVGK GRFAEVYKAK LKQNTSEQFE TVAVKIFP; Positive Samples: HT-29, A-549, Mouse lung; Cellular Location: Cell membrane, Single-pass type I membrane protein

A total of three members of the TGF beta family, TGFbeta1, TGFbeta2 and TGFbeta3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFbetas mediate their activity by high affinity binding to the type II receptor 70kDa transmembrane protein with a cytoplasmic serine-threonine kinase domain.

Specifications

• Antigen: TGFBR2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TGFBR2
• Gene Symbols: TGFBR2
• Immunogen: Recombit fusion protein containing a sequence corresponding to amino acids 23-280 of human TGFBR2
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1.48 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P37173, P38438, Q62312
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21813, 7048, 81810
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid