Invitrogen™ TGM2 Recombinant Rabbit Monoclonal Antibody (JU30-02)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA532819

Catalog No. PIMA532819

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.

Specifications

• Antigen: TGM2
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P21980, P21981
• Gene Symbols: TGM2
• Immunogen: Synthetic peptide within Human Transglutaminase 2 aa 578-627.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: JU30-02
• Conjugate: Unconjugated
• Gene: TGM2
• Gene Alias: C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; G alpha h; G[a]h; G-ALPHA-h; GNAH; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; RP5-1054A22.2; TG C; TG(C); TG2; TGase C; TGase H; TGase2; TGase-2; TGase-H; TgaseII; TGC; TGM2; Tissue transglutaminase; Tissue type transglutaminase; tissue-type transglutaminase; transglutaminase; transglutaminase 2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Transglutaminase 2 C polypeptide; transglutaminase 2, C polypeptide; transglutaminase C; Transglutaminase H; transglutaminase-2; tTG; tTGas
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 21817, 7052
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid