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  5. Tocris Bioscience™ TH 5427 Hydrochloride

Tocris Bioscience™ TH 5427 Hydrochloride
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Catalog No. 653410
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65-341-0 10 mg
65-345-0 50 mg
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Catalog No. 65-341-0 Supplier Tocris Bioscience™ Supplier No. 6534/10
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Description

Potent NUDT5 inhibitor

TH 5427 hydrochloride is a potent nudix hydrolase 5 (NUDT5) inhibitor (IC50 = 29 nM). Displays >650-fold selectivity for NUDT5 over MTH1. Inhibits ATP synthesis, chromatin remodeling, gene expression and proliferation in progestin-treated breast cancer cells in vitro.

Specifications

Chemical Name or Material 7-[[5-(3,4-Dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-(piperazine-1-yl)-1H-purine-2,6-dione hydrochloride
Quantity 10 mg
Molecular Formula C20H20Cl2N8O3.HCl
Formula Weight 527.79
Purity 98%
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