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  5. R&D Systems™ TH 9619 disodium salt

R&D Systems™ TH 9619 disodium salt
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Catalog No. 771950 Shop All Novus Products
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77-195-0 50 mg
77-191-0 10 mg
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Catalog No. 77-195-0 Supplier R&D Systems™ Supplier No. 7719/50

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Description

A Tocris product, part of R&D Systems. MTHFD2 inhibitor

TH 9619 disodium salt is a potent and selective methylenetetrahydrofolate dehydrogenase inhibitor (MTHFD2; IC50 = 47 nM). It shows efficacity on HL-60 cell viability with EC50 of 11nM. In vitro, It shows antiproliferative efficacy in acute myeloid leukemia (AmL) cells and T-ALL Jurkat cells. In vivo, TH9619 disodium salt impairs cancer progression in a mouse disease model of AmL.

Specifications

Chemical Name or Material Disodium N-[[5-[[2-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetyl]amino]-3-fluoro-2-pyridinyl]carbonyl]-L-glutamate
Quantity 50 mg
Product Line Tocris
Target Dehydrogenase Inhibitors
Molecular Formula C17H16FN7Na2O7
Purity 0.98
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