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Tocris Bioscience™ THAL SNS 032
GREENER_CHOICE

Catalog No. 65325
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Quantity:
5 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Potent and selective Cdk9 Degrader (PROTAC™)

PROTAC comprising the cyclin-dependent kinase inhibitor SNS 032 (Cat. No. 4075) conjugated to the cereblon E3 ligase ligand, thalidomide (Cat. No. 0652). Potent, selective and cereblon-dependent degrader of Cdk9 (EC50 = 4 nM). Displays >15-fold selectivity for Cdk9 over other CDKs (EC50 values are 62, 171 and 398 nM for Cdk2, Cdk1 and Cdk7, respectively). Induces complete degradation of Cdlk9 at 250 nM in MOLT4 cells. Inhibits proliferation of leukemia cell lines.

THAL SNS 032 is a degrader (PROTAC®) comprising the cyclin-dependent kinase inhibitor SNS 032 (Cat. No. 4075) conjugated to the cereblon E3 ligase ligand, thalidomide (Cat. No. 0652). Potent, selective and cereblon-dependent degrader of Cdk9 (EC50 = 4 nM). Displays >15-fold selectivity for Cdk9 over other CDKs (EC50 values are 62, 171 and 398 nM for Cdk2, Cdk1 and Cdk7, respectively). Induces complete degradation of Cdk9 at 250 nM in MOLT4 cells. Inhibits proliferation of leukemia cell lines.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxo-6,9,12-trioxa-3-azatetradecyl)piperidine-4-carboxamide
CAS 2139287-33-3
Quantity 5 mg
Molecular Formula C40H52N8O10S2
Formula Weight 869.02
Purity 98%
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