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R&D Systems™ Thalidomide, propargyl
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Catalog No. 668550 Shop All Novus Products
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66-855-0 50 mg
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Catalog No. 66-855-0 Supplier R&D Systems™ Supplier No. 6685/50

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Description

A Tocris product, part of R&D Systems. Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTAC™s

Thalidomide, propargyl is a click-activated Thalidomide (Cat.No. 0652); can be used as a precursor to a PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with an alkyne functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch .

Specifications

Chemical Name or Material 2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione
CAS 2098487-39-7
Quantity 50 mg
Product Line Tocris
Molecular Formula C16H12N2O5
Formula Weight 312.28
Product Type Alkyne-functionalized Ligand
Purity 95%
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