Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Invitrogen™ THEM4 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA517637
Description
It is not recommended to aliquot this antibody.
THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.
Specifications
THEM4 | |
Polyclonal | |
0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 | |
Q3UUI3, Q566R0, Q5T1C6 | |
THEM4 | |
Synthetic peptide corresponding to residues of human CTMP. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Flow Cytometry, Immunoprecipitation, Western Blot | |
Unconjugated | |
THEM4 | |
2700077M13Rik; 4921507I02Rik; Acyl-CoA thioesterase THEM4; acyl-coenzyme A thioesterase THEM4; carboxyl-terminal modulator protein; C-terminal modulator protein; CTMP; RGD1304723; THEM4; Thioesterase superfamily member 4 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
117145, 361992, 75778 | |
-20°C | |
Liquid |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction