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Invitrogen™ THEM4 Polyclonal Antibody
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Catalog No. PIPA5110484
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100 μL
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PIPA5110484 100 μL
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Catalog No. PIPA5110484 Supplier Invitrogen™ Supplier No. PA5110484
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SSEEVILKDC SVPNPSWNKD LRLLFDQFMK KCEDGSWKRL PSYKRTPTEW IQDFKTHFLD PKLMKEEQMS QAQLFTRSFD DGLGFEYVMF YNDIEKRMVC LFQGGPYLEG PPGF.

THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.
TRUSTED_SUSTAINABILITY

Specifications

Antigen THEM4
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.27 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene THEM4
Gene Accession No. Q3UUI3, Q5T1C6
Gene Alias 2700077M13Rik; 4921507I02Rik; Acyl-CoA thioesterase THEM4; acyl-coenzyme A thioesterase THEM4; carboxyl-terminal modulator protein; C-terminal modulator protein; CTMP; RGD1304723; THEM4; Thioesterase superfamily member 4
Gene Symbols THEM4
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 37-150 of human THEM4 (NP_444283.2).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117145, 75778
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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