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Invitrogen™ THEM4 Polyclonal Antibody
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Catalog No. PIPA5143977
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100 μg
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Catalog No. Quantity
PIPA5143977 100 μg
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Catalog No. PIPA5143977 Supplier Invitrogen™ Supplier No. PA5143977
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Description

Rabbit Polyclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human HepG2 whole cell, human K562 whole cell. ICC/IF: PC-3 cell. Flow: U87 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.
TRUSTED_SUSTAINABILITY

Specifications

Antigen THEM4
Applications ELISA, Flow Cytometry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and no preservative
Gene THEM4
Gene Accession No. Q5T1C6
Gene Alias 2700077M13Rik; 4921507I02Rik; Acyl-CoA thioesterase THEM4; acyl-coenzyme A thioesterase THEM4; carboxyl-terminal modulator protein; C-terminal modulator protein; CTMP; RGD1304723; THEM4; Thioesterase superfamily member 4
Gene Symbols THEM4
Host Species Rabbit
Immunogen E.coli-derived human THEM4 recombinant protein (Position: M1-T240).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117145
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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