Thiamphenicol

Description

The methyl-sulfonyl analogue of chloramphenicol | CAS: 15318-45-3 | C12H15Cl2NO5S | 356.214 g/mol

Thiamphenicol is used to treat chancroid in men and uncomplicated gonorrhea. It is used in studies of bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit. It is used to study chloraniphenicol-thiamphenicol-resistance and the use of fluorinated analogs when resistance is encountered. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Thiamphenicol is used to treat chancroid in men and uncomplicated gonorrhea. It is used in studies of bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit. It is used to study chloraniphenicol-thiamphenicol-resistance and the use of fluorinated analogs when resistance is encountered. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.

Solubility
Soluble in acetonitrile or DMF. Slightly soluble in water

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Specifications

Chemical Identifiers

• CAS: 15318-45-3
• Molecular Formula: C12H15Cl2NO5S
• Molecular Weight (g/mol): 356.214
• MDL Number: MFCD00467983
• InChI Key: OTVAEFIXJLOWRX-NXEZZACHSA-N
• Synonym: thiamphenicol, thiophenicol, thiamcol, +-thiamphenicol, raceophenidol, thiocymetin, dextrosulphenidol, thiamphenicolum, d-thiocymetin, d-thiophenicol
• PubChem CID: 27200
• ChEBI: CHEBI:32215
• IUPAC Name: 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
• SMILES: CS(=O)(=O)C1=CC=C(C=C1)C(C(CO)NC(=O)C(Cl)Cl)O

• Color: White to Yellow
• Quantity: 5 g
• Beilstein: 2819542
• Merck Index: 14,9301
• Solubility Information: Soluble in acetonitrile or DMF; Slightly soluble in water
• Formula Weight: 356.22
• Physical Form: Powder
• Chemical Name or Material: Thiamphenicol

Safety and Handling

EINECSNumber	239-355-3
RTECSNumber	AB6680000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only