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Invitrogen™ Thioredoxin 1 Polyclonal Antibody
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Catalog No. PIPA584265
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100 μL
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PIPA584265 100 μL
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Catalog No. PIPA584265 Supplier Invitrogen™ Supplier No. PA584265
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MVKQIESKTA FQEALDAAGD KLVVVDFSA Highest antigen sequence indentity to the following orthologs: Mouse - 90%, Rat - 66%.

Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53, NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Thioredoxin 1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TXN
Gene Accession No. P10599
Gene Alias ADF; ATL-derived factor; AW550880; DKFZp686B1993; MGC61975; RP11-427L11.1; SASP; surface-associated sulphydryl protein; testicular tissue protein Li 199; thioredoxin; thioredoxin 1; thioredoxin delta 3; TRDX; TRX; TRX1; Txn; TXN delta 3; Txn1
Gene Symbols TXN
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TXN. Recombinant protein control fragment (Product #RP-104202).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7295
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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