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Invitrogen™ Thioredoxin 2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA587276
Description
Purity is > 95% by SDS-PAGE.
Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cystein residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53, NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
Specifications
Thioredoxin 2 | |
Polyclonal | |
Unconjugated | |
TXN2 | |
2510006J11Rik; AI788873; COXPD29; G7746; hypothetical protein LOC402938; LMA1; mitochondrial thioredoxin; MTRX; mt-Trx; thioredoxin 2; Thioredoxin II; thioredoxin nuclear gene encoding mitochondrial protein; thioredoxin TRX2; thioredoxin, mitochondrial; Thioredoxin-1; Thioredoxin2; Thioredoxin-2; TR-II; TRX1; Trx2; TRX-2; Txn2; YGR209C; zgc:77127 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
25828, 281557, 56551, 79462 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot, Immunohistochemistry (Paraffin), Western Blot, Western Blot | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2 | |
P97493, P97615, Q95108, Q99757 | |
TXN2 | |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Trx2. | |
100 μL | |
Primary | |
Human, Mouse, Rat, Bovine | |
Antibody | |
IgG |
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