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Thioredoxin 2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501986016
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50-198-6016 100 μL
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Catalog No. 50-198-6016 Supplier Bioss Supplier No. BS4256R
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Description

Rabbit Polyclonal Antibody

Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cystein residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53 , NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.

Specifications

Antigen Thioredoxin 2
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene TXN2
Gene Accession No. Q99757
Gene Alias 2510006J11Rik; AI788873; BOS_5708; COXPD29; G7746; hypothetical protein LOC402938; LMA1; mitochondrial thioredoxin; MTRX; MT-TRX; thioredoxin 2; Thioredoxin II; thioredoxin nuclear gene encoding mitochondrial protein; thioredoxin TRX2; Thioredoxin, mitochondrial; Thioredoxin-1; Thioredoxin2; Thioredoxin-2; TR-II; TRX1; TRX2; TRX-2; Txn2; YGR209C; zgc:77127
Gene Symbols TXN2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Thioredoxin 2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25828
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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