Invitrogen™ THOC5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588191

Catalog No. PIPA588191

Description

Immunogen sequence: FKSKHEEIDL VSLEEFYKEA PPDISKAEVT MGDPHQQTLA RLDWELEQRK RLAEKYRECL SNKEKILKEI EVKKEYLSSL QPRLNSIMQA SLPVQEYLFM PFDQAHKQYE TARHLPPPLY VLFVQATAYG QACDKTLSVA IEGSVDEAKA LFKPPEDSQD DESDSDAEEE QTTKRRRPTL GVQLDDKRKE MLKRHPLSVM LDLKCKDDSV LHLTFYYLMN L; Positive Samples: HT-29, Mouse testis, Rat testis; Cellular Location: Cytoplasm, Nucleus, Nucleus speckle.

Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and THOC4. UAP56 functions as a bridge between THOC4 and the THO complex. THOC5 in conjunction with THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. May be involved in the differentiation of granulocytes and adipocytes.

Specifications

• Antigen: THOC5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: THOC5
• Gene Alias: 1700060C24Rik; A430085L24Rik; C22orf19; Fmip; Fms interacting protein; Fms-interacting protein; fSAP79; Functional spliceosome-associated protein 79; hTREX90; KIAA0983; NF2/meningioma region protein pK1.3; PK1.3; placental protein 39.2; PP39.2; serum/glucocorticoid regulated kinase 2; Sgk2; THO complex 5; THO complex subunit 5 homolog; Thoc5
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 107829, 360972, 8563
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.03 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q13769, Q68FX7, Q8BKT7
• Gene Symbols: THOC5
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 150-370 of human THOC5 (NP_0036694).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG