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Invitrogen™ THOC5 Polyclonal Antibody
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Catalog No. PIPA588191
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100 μL
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PIPA588191 100 μL
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Catalog No. PIPA588191 Supplier Invitrogen™ Supplier No. PA588191
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FKSKHEEIDL VSLEEFYKEA PPDISKAEVT MGDPHQQTLA RLDWELEQRK RLAEKYRECL SNKEKILKEI EVKKEYLSSL QPRLNSIMQA SLPVQEYLFM PFDQAHKQYE TARHLPPPLY VLFVQATAYG QACDKTLSVA IEGSVDEAKA LFKPPEDSQD DESDSDAEEE QTTKRRRPTL GVQLDDKRKE MLKRHPLSVM LDLKCKDDSV LHLTFYYLMN L; Positive Samples: HT-29, Mouse testis, Rat testis; Cellular Location: Cytoplasm, Nucleus, Nucleus speckle.

Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and THOC4. UAP56 functions as a bridge between THOC4 and the THO complex. THOC5 in conjunction with THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. May be involved in the differentiation of granulocytes and adipocytes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen THOC5
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.03 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene THOC5
Gene Accession No. Q13769, Q68FX7, Q8BKT7
Gene Alias 1700060C24Rik; A430085L24Rik; C22orf19; Fmip; Fms interacting protein; Fms-interacting protein; fSAP79; Functional spliceosome-associated protein 79; hTREX90; KIAA0983; NF2/meningioma region protein pK1.3; PK1.3; placental protein 39.2; PP39.2; serum/glucocorticoid regulated kinase 2; Sgk2; THO complex 5; THO complex subunit 5 homolog; Thoc5
Gene Symbols THOC5
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 150-370 of human THOC5 (NP_0036694).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 107829, 360972, 8563
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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