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Invitrogen™ THOC5 Polyclonal Antibody
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Catalog No. PIPA5119821
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100 μL
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PIPA5119821 100 μL
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Catalog No. PIPA5119821 Supplier Invitrogen™ Supplier No. PA5119821
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Description

Rabbit Polyclonal Antibody

Positive Control: NIH/3T3 cell lysate, PC-12 cell lysate, Hela cell lysate, HepG2 cell lysate, human ovarian tumor tissue, mouse brain tissue. Subcellular Location: Nucleus, Cytoplasm.

Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and THOC4. UAP56 functions as a bridge between THOC4 and the THO complex. THOC5 in conjunction with THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. May be involved in the differentiation of granulocytes and adipocytes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen THOC5
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene THOC5
Gene Accession No. Q13769, Q68FX7, Q8BKT7
Gene Alias 1700060C24Rik; A430085L24Rik; C22orf19; Fmip; Fms interacting protein; Fms-interacting protein; fSAP79; Functional spliceosome-associated protein 79; hTREX90; KIAA0983; NF2/meningioma region protein pK1.3; PK1.3; placental protein 39.2; PP39.2; serum/glucocorticoid regulated kinase 2; Sgk2; THO complex 5; THO complex subunit 5 homolog; Thoc5
Gene Symbols THOC5
Host Species Rabbit
Immunogen Recombinant protein within human THOC5 aa 1-200.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 107829, 360972, 8563
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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