Invitrogen™ THRA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1216

Catalog No. PA1-216

Description

PA1-216 detects the thyroid hormone receptor alpha 2 from human and mouse samples. PA1-216 has been successfully used in Western blot, ICC/IF and immunohistochemistry (paraffin) procedures. By Western blot, this antibody detects bands at ~58 kDa representing Tra2 in mouse tissue. This antibody also detects a ~43 kDa protein which is believed to be non-specific. The PA1-216 immunizing peptide corresponds to amino acid residues 455-469 from rat thyroid hormone receptor alpha 2.

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Specifications

• Antigen: THRA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Thra
• Gene Alias: 6430529J03Rik; AR7; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1; AW259572; cerbA protein; c-erb-A protein; c-erb-A thyroid hormone receptor; c-ERBA-1; cerbAalpha; c-erbAalpha; c-erbA-alpha; c-erbAalpha2; c-erbA-alpha2; c-erbAalpha2; thyroid hormone receptor alpha; CHNG6; E ERB-T-1; EAR7; EAR-7; ERBA; ERBA ALPHA; ERBA related 7; ERBA1; ERBA-related 7; ERB-T-1; MGC000261; MGC43240; NR1A1; Nuclear receptor subfamily 1 group A member 1; Oncogene ERBA; Rvr; T3R[a]; T3Ralpha; Thra; THRA1; THRA2; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1); thyroid hormone receptor alpha 2; thyroid hormone receptor beta; thyroid hormone receptor, alpha; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; TR; TR alpha 1; TR alpha 1+2; TR alpha 2; triiodothyronine receptor; unnamed protein product; V-erbA-related protein 7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21833, 7067
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 1 mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: P10827, P63058
• Gene Symbols: Thra
• Immunogen: Synthetic Peptide: S(455) R A V C G E D D S S E A S S(469).
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG