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Invitrogen™ THRA/THRB Monoclonal Antibody (H43), APC
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Catalog No. PIMA545921
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100 μg
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Catalog No. Quantity
PIMA545921 100 μg
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Catalog No. PIMA545921 Supplier Invitrogen™ Supplier No. MA545921
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Description

Mouse Monoclonal Antibody

A 1:500 dilution of MA5-45921 was sufficient for detection of Pan-Thyroid hormone receptor in 10 μg of Hep G2 Human Hepatoblastoma Cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects 70 kDa.

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen THRA/THRB
Applications ELISA, Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone H43
Concentration 1 mg/mL
Conjugate APC
Formulation 2.48mM MES, 95.46mM phosphate with 2mM EDTA and no preservative; pH 7.4
Gene THRB
Gene Accession No. P10827, P10828, P18113, P37242, P63058, P63059
Gene Alias 6430529J03Rik; AR7; AW259572; c-erbA-1; C-ERBA-2; c-erbAalpha; c-erbA-alpha; C-ERBA-BETA; CHNG6; EAR7; EAR-7; Erba; ERBA1; ERBA2; ERBA-related 7; ERB-T-1; GRTH; Nr1a1; NR1A2; Nuclear receptor subfamily 1 group A member 1; nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; PRTH; Rvr; T3R[a]; T3Ralpha; THR; THR1; THRA; THRA1; THRA2; THRB; THRB1; THRB2; thyroid hormone nuclear receptor beta variant 1; thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor beta; thyroid hormone receptor, alpha; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); thyroid normone nuclear receptor alpha variant 1; TR; TR alpha 1; TR alpha 2; triiodothyronine receptor; V-erbA-related protein 7
Gene Symbols THRA, THRB
Host Species Mouse
Immunogen Synthetic peptide from the full length Human Thyroid hormone receptor protein.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21833, 21834, 24831, 7067, 7068, 81812
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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