Invitrogen™ THRA/THRB Monoclonal Antibody (H43), PerCP

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA545923

Catalog No. PIMA545923

Description

A 1:500 dilution of MA5-45923 was sufficient for detection of Pan-Thyroid hormone receptor in 10 μg of Hep G2 Human Hepatoblastoma Cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects 70 kDa.

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.

Specifications

• Antigen: THRA/THRB
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
• Gene Accession No.: P10827, P10828, P18113, P37242, P63058, P63059
• Gene Symbols: THRA, THRB
• Immunogen: Synthetic peptide from the full length Human Thyroid hormone receptor protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Immunohistochemistry, Western Blot, Immunocytochemistry
• Clone: H43
• Conjugate: PerCP
• Gene: THRA
• Gene Alias: 6430529J03Rik; AR7; AW259572; c-erbA-1; C-ERBA-2; c-erbAalpha; c-erbA-alpha; C-ERBA-BETA; CHNG6; EAR7; EAR-7; Erba; ERBA1; ERBA2; ERBA-related 7; ERB-T-1; GRTH; Nr1a1; NR1A2; Nuclear receptor subfamily 1 group A member 1; nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; PRTH; Rvr; T3R[a]; T3Ralpha; THR; THR1; THRA; THRA1; THRA2; THRB; THRB1; THRB2; thyroid hormone nuclear receptor beta variant 1; thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor beta; thyroid hormone receptor, alpha; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); thyroid normone nuclear receptor alpha variant 1; TR; TR alpha 1; TR alpha 2; triiodothyronine receptor; V-erbA-related protein 7
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 21833, 21834, 24831, 7067, 7068, 81812
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov