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Invitrogen™ THRB Monoclonal Antibody (2386)
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Catalog No. MA14677
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100 μL
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MA14677 100 μL
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Catalog No. MA14677 Supplier Invitrogen™ Supplier No. MA14677
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Description

Mouse Monoclonal Antibody

This antibody is specific for the ~55 kDa THR-beta protein.

Thyroid hormone receptors (TR), also known as c-erbA-2, are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences called hormone response elements following activation by the appropriate hormone. Thyroid hormones, through their interaction with TR, effect metabolic processes, growth and development in many tissues by regulating the expression of genes for growth hormone, malic enzyme and several hepatic proteins. There are two forms of TR; TR alpha (on chromosome 17) and TR beta (on chromosome 3). Each of these isoforms also has two isoforms; TR alpha-1 and TRv alpha-2, and TR beta-1 and TR beta-2 respectively. TR alpha-1 and 2 are identical through amino acid 370 where their sequences diverge. TRv alpha-2, which does not bind T3 and is a strong negative regulator of the functional TR, is 80 amino acids longer than TR alpha-1. The corresponding gene for the thyroid hormone receptor beta-1 is NR1A2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen THRB
Applications Western Blot
Classification Monoclonal
Clone 2386
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
Gene THRB
Gene Accession No. P10828
Gene Alias c-erbA-2; c-erbAbeta; C-ERBA-BETA; ERBA 2; ERBA BETA; ERBA2; ERBA-BETA; fj24f03; GRTH; LOW QUALITY PROTEIN: thyroid hormone receptor beta; MGC126109; MGC126110; NR1A2; Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; PRTH; RATT3REC; si:ch211-264a6.2; T3R[b]; T3Rbeta; T3rec; THR; THR1; thr2; Thrb; Thrb1; Thrb2; thyroid hormone nuclear receptor beta variant 1; thyroid hormone receptor beta; thyroid hormone receptor beta 1; thyroid hormone receptor beta 2; thyroid hormone receptor beta 3; thyroid hormone receptor beta1; thyroid hormone receptor beta-1; thyroid hormone receptor beta2; thyroid hormone receptor beta2delta; thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); TR; TR beta; TR beta 1; TR[b]1; trb; TR-B1C-ERBA-2; TRbeta; TR-beta; TRbeta1; TRbeta2Delta; wu:fj24f03
Gene Symbols THRB
Host Species Mouse
Immunogen Synthetic peptide corresponding to the N-terminal region of human THRB conjugated to KLH.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7068
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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