Thrombomodulin Monoclonal Antibody (QBEND/40), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA516928

Catalog No. PIMA516928

Description

Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. A suggested positive control for immunohistochemical applications is lymph node. For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL.

Thrombomodulin (TM) is also known as Fetomodulin (FM), endothelial anticoagulant protein, or glycoprotein P112. Thrombomodulin contains six repeated domains homologous with epidermal growth factor (EGF) and an amino terminal domain homologous to lectin-like protein. Through its accelerated activation of protein C, synthesis of TM is one of several mechanisms important in maintaining thrombo-resistance and thus reducing clot formation on the surface of the endothelial cells. Immunohistochemical staining of formalin-fixed tissue for TM has been used for the study of a variety of vascular tumors, meningiomas and choriocarcinomas.

Specifications

• Antigen: Thrombomodulin
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: tissue culture supernatant diluted in 0.2M tris HCl with 5-10% FBS and 0.1% sodium azide; pH 7.4
• Gene Accession No.: P07204
• Gene Symbols: THBD
• Immunogen: Human endothelium (thrombomodulin)
• Regulatory Status: RUO
• Gene ID (Entrez): 100008887, 7056
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
• Clone: QBEND/40
• Conjugate: Unconjugated
• Gene: THBD
• Gene Alias: AHUS6; AI385582; BDCA3; BDCA-3; CD141; CD141 antigen; DC141; fetomodulin; sCD141; snoRNA MBII-339; soluble CD141; THBD; THPH12; THRM; thrombomdulin; thrombomodulin; thrombomodulin precursor; TM
• Host Species: Mouse
• Quantity: 1 mL
• Primary or Secondary: Primary
• Target Species: Human, Rabbit
• Product Type: Antibody
• Isotype: IgG2a