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Invitrogen™ Thrombopoietin Polyclonal Antibody
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Catalog No. PIPA5116038
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PIPA5116038 100 μL
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Catalog No. PIPA5116038 Supplier Invitrogen™ Supplier No. PA5116038
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Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total THPO.

Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Thrombopoietin
Applications Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene THPO
Gene Accession No. P40225, P40226, P49745
Gene Alias C-mpl ligand; Megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; megakaryocyte stimulating factor; Mgdf; MKCSF; ML; MPL ligand; Mpllg; MSA; Myeloproliferative leukemia virus oncogene ligand; prepro-thrombopoietin; TDH2A; THCYT1; THPO; Thrombopoietin; thyroid microsomal antigen; thyroid peroxidase; thyroperoxidase; Tpo; TPX
Gene Symbols THPO
Host Species Rabbit
Immunogen A synthesized peptide derived from human THPO(Accession P40225), corresponding to amino acid residues T257-F307.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 108348162, 21832, 7066, 81811
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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