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Thrombopoietin Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501980856
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50-198-0856 100 μL
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Catalog No. 50-198-0856 Supplier Bioss Supplier No. BS10407R
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Description

Rabbit Polyclonal Antibody

Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.

Specifications

Antigen Thrombopoietin
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene THPO
Gene Accession No. P40225
Gene Alias C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; megakaryocyte stimulating factor; MGDF; MKCSF; ML; MPL ligand; Mpllg; Myeloproliferative leukemia virus oncogene ligand; prepro-thrombopoietin; THCYT1; THPO; Thrombopoietin; TPO
Gene Symbols THPO
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Thrombopoietin.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7066
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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