Invitrogen™ Thromboxane synthase Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596025

Catalog No. PIPA596025

Description

Positive Samples: A-549, HT-29, U-937, NCI-H460; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein Immunogen sequence: TYLLATNPDC QEKLLREVDV FKEKHMAPEF CSLEEGLPYL DMVIAETLRM YPPAFRFTRE AAQDCEVLGQ RIPAGAVLEM AVGALHHDPE HWPSPETFNP ERFTAEARQQ HRPFTYLPFG AGPRSCLGVR LGLLEVKLTL LHVLHKFRFQ ACPETQVPLQ LESKSALGPK NGVYIKIVSR.

Thromboxane synthase encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: Thromboxane synthase
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TBXAS1
• Gene Alias: BDPLT14; CYP5; Cyp5a1; cytochrome P450 5A1; cytochrome P450, family 5, subfamily A, polypeptide 1; FLJ52771; GHOSAL; platelet, cytochrome P450, subfamily V; similar to Thromboxane-A synthase (TXA synthase) (TXS); Tbxas1; THAS; ThromboxA ane synthase 1; thromboxane A synthase 1; thromboxane A synthase 1 (platelet); thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A); thromboxane A synthase 1, platelet; thromboxane synthase; thromboxane-A synthase; TS; TXA synthase; TXAS; TXS
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21391, 24886, 6916
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.18 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: P24557, P36423, P49430
• Gene Symbols: TBXAS1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 355-534 of human Thromboxane synthase (NP_0010522).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG