Thymidylate Synthase Antibody (SPM453), Janelia Fluor™ 549, Novus Biologicals™

Catalog No.	Quantity
N234441J549	0.1 mL

Catalog No. N234441J549 Supplier Novus Biologicals Supplier No. NBP234441JF549

Description

Mouse Monoclonal Antibody

Thymidylate Synthase Monoclonal specifically detects Thymidylate Synthase in Human samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Flow (Intracellular).

Specifications

• Antigen: Thymidylate Synthase
• Applications: Western Blot, Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: SPM453
• Conjugate: Janelia Fluor 549
• Dilution: Western Blot, Flow Cytometry, ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Alias: EC 2.1.1.45, HsT422, MGC88736, thymidylate synthase, thymidylate synthetase, TMSTsase, TSase, TSHST422
• Gene Symbols: TYMS
• Host Species: Mouse
• Immunogen: Recombinant full-length human Thymidylate Synthase protein. (Uniprot: P04818 )
• Purification Method: Protein A or G purified
• Quantity: 0.1 mL
• Research Discipline: Cancer, Cell Cycle and Replication, DNA Repair, DNA replication Transcription Translation and Splicing, Transcription Factors and Regulators, Translation Control
• Primary or Secondary: Primary
• Gene ID (Entrez): 7298.0
• Test Specificity: It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
• Target Species: Human
• Content And Storage: Store at 4°C in the dark.
• Isotype: IgG1 κ