Thymidylate Synthase Antibody (TS106), DyLight 550, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP234502R

Catalog No. NBP234502R

Description

Thymidylate Synthase Monoclonal specifically detects Thymidylate Synthase in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Thymidylate Synthase
• Classification: Monoclonal
• Conjugate: DyLight 550
• Gene Alias: EC 2.1.1.45, HsT422, MGC88736, thymidylate synthase, thymidylate synthetase, TMSTsase, TSase, TSHST422
• Host Species: Mouse
• Molecular Weight of Antigen: 36 kDa
• Quantity: 0.1 mL
• Research Discipline: Cancer, Cell Cycle and Replication, DNA Repair, DNA replication Transcription Translation and Splicing, Transcription Factors and Regulators, Translation Control
• Gene ID (Entrez): 7298
• Target Species: Human
• Form: Purified

• Applications: Western Blot, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
• Clone: TS106
• Dilution: Western Blot, ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
• Gene Symbols: TYMS
• Immunogen: Recombinant full-length human Thymidylate Synthase protein. (Uniprot: P04818 )
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
• Content And Storage: Store at 4C in the dark.
• Isotype: IgG1 κ

For Research Use Only