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Invitrogen™ Thymidylate Synthase Recombinant Rabbit Monoclonal Antibody (2B2)
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Catalog No. PIMA538366
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100 μL
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PIMA538366 100 μL
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Catalog No. PIMA538366 Supplier Invitrogen™ Supplier No. MA538366
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody has been tested in direct-ELISA.

Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Thymidylate Synthase
Applications Western Blot
Classification Recombinant Monoclonal
Clone 2B2
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 150mM NaCl and 0.02% sodium azide; pH 7.4
Gene TYMS
Gene Accession No. P04818
Gene Alias HST422; MGC88736; OK/SW-cl.29; Thymidylate synthase; thymidylate synthetase; TMS; TS; Tsase; Tyms; tysy
Gene Symbols TYMS
Host Species Rabbit
Immunogen A synthesized peptide derived from human Thymidylate Synthase.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7298
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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