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Thymidylate Synthase Monoclonal Antibody (TS 106), Invitrogen™

Catalog No. PIMA513512
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500 μL
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Catalog No. Quantity
PIMA513512 500 μL
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Catalog No. PIMA513512 Supplier Thermo Scientific Supplier No. MA513512

Description

Mouse Monoclonal Antibody

MA5-13512 targets Thymidylate Synthase in ELISA, FACS, IF, IP, and WB applications and shows reactivity with Human samples. The MA5-13512 immunogen is recombinant human TS enzyme.

Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Thymidylate Synthase
Applications ELISA, Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone TS 106
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene TYMS
Gene Accession No. P04818
Gene Alias HST422; MGC88736; OK/SW-cl.29; Thymidylate synthase; thymidylate synthetase; TMS; TS; Tsase; Tyms; tysy
Gene Symbols TYMS
Host Species Mouse
Immunogen Recombinant human TS enzyme
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7298
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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