Invitrogen™ Thymidylate Synthase Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522263

Catalog No. PIPA522263

Description

Recommended positive controls: A549, H1299, HCT116. Predicted reactivity: Mouse (94%), Rat (95%), Zebrafish (88%), Xenopus laevis (85%), Dog (96%), Pig (96%), Rhesus Monkey (98%), Chimpanzee (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Specifications

• Antigen: Thymidylate Synthase
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TYMS
• Gene Alias: HST422; MGC88736; OK/SW-cl.29; Thymidylate synthase; thymidylate synthetase; TMS; TS; Tsase; Tyms; tysy
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7298
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P04818
• Gene Symbols: TYMS
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Thymidylate synthase. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG