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Invitrogen™ Thymidylate Synthase Polyclonal Antibody

Catalog No. PIPA5121547
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200 μL
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PIPA5121547 20 μL
PIPA5119461 200 μL
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Catalog No. PIPA5121547 Supplier Invitrogen™ Supplier No. PA5121547
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Description

Rabbit Polyclonal Antibody

Thymidylate Synthase Polyclonal Antibody for ICC/IF, IHC (P), Western Blot

Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Thymidylate Synthase
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene TYMS
Gene Accession No. P04818, P45352
Gene Alias HST422; MGC88736; OK/SW-cl.29; Thymidylate synthase; thymidylate synthetase; TMS; TS; Tsase; Tyms; tysy
Gene Symbols TYMS
Host Species Rabbit
Immunogen Recombinant protein Thymidylate Synthetase. The antigen corresponds to amino acid range 36-313 of the target protein.
Purification Method Antigen affinity chromatography, Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29261, 7298
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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