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Invitrogen™ Thymidylate Synthase Polyclonal Antibody
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Catalog No. PIPA587901
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100 μL
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PIPA587901 100 μL
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Catalog No. PIPA587901 Supplier Invitrogen™ Supplier No. PA587901
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MPVAGSELPR RPLPPAAQER DAEPRPPHGE LQYLGQIQHI LRCGVRKDDR TGTGTLSVFG MQARYSLRDE FPLLTTKRVF WKGVLEELLW FIKGSTNAKE LSSKGVKIWD ANGSRDFLDS LGFSTREEGD LGPVYGFQWR HFGAEYRDME SDYSGQGVDQ LQRVIDTIKT NPDDRRIIMC AWNPRDLPLM ALPPCHALCQ FYVVNSELSC QLYQRSGDMG LGVPFNIASY ALLTYMIAHI TGLKPGDFIH TLGDAHIYLN HIEPLKIQLQ REPRPFPKLR ILRKVEKIDD FKAEDFQIEG YNPHPTIKME MAV; Positive Samples: A-431, Jurkat, DU145, Mouse kidney, Mouse spleen; Cellular Location: Cytoplasm, Mitochondrion, Mitochondrion inner membrane, Mitochondrion matrix, Nucleus.

Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Thymidylate Synthase
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 2.12 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene TYMS
Gene Accession No. P04818, P07607
Gene Alias HST422; MGC88736; OK/SW-cl.29; Thymidylate synthase; thymidylate synthetase; TMS; TS; Tsase; Tyms; tysy
Gene Symbols TYMS
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human TYMS (NP_0010621).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22171, 7298
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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