Thymosin Alpha-1 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-0158	100 μL

Catalog No. 50-198-0158 Supplier Bioss Supplier No. BS0226R

Description

Rabbit Polyclonal Antibody

The thymus gland produces several hormones or hormone-like substances which are derived from a polypeptide precursor containing (in the rat) 113 amino acids and known as prothymosin-alpha. A peptide containing 28 amino acid residues, named thymosin-alpha-1, was originally isolated from calf thymosin fraction 5 and shown to restore various aspects of immune function in several in vitro and invivo test systems. Thymosin-alpha-1 was subsequently isolated from a similar fraction from human thymosin and reported to have the same amino acid sequence as bovine thymosin-alpha-1. In 2003, Jiang et al. identified a pathway that regulates mitochondria-initiated caspase activity. In this pathway, putative human HLA class II-associated protein (PHAP) promoted caspase-9 activation after apoptosome formation, whereas prothymosin-alpha-1 negatively regulated caspase-9 activation by inhibiting apoptosome formation.

Specifications

• Antigen: Thymosin Alpha-1
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: PTMA
• Gene Accession No.: P06454
• Gene Alias: alpha-prothymosin; gene sequence 28; Prothymosin alpha; prothymosin alpha protein; Prothymosin alpha, N-terminally processed; prothymosin, alpha; prothymosin-alpha; Ptma; Thym; Thymosin alpha; Thymosin alpha-1; TMSA; TMSB4; TMSB4X
• Gene Symbols: PTMA
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human Thymosin Alpha-1.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5757
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG