Thyroglobulin Antibody (2H11 + 6E1), FITC, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP234530F

Catalog No. NB006113

Description

Thyroglobulin Monoclonal specifically detects Thyroglobulin in Human, Mouse, Rat samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Thyroglobulin
• Classification: Monoclonal
• Conjugate: FITC
• Formulation: PBS with 0.05% Sodium Azide
• Gene Symbols: TG
• Immunogen: Human thyroid follicular cells
• Quantity: 0.1 mL
• Research Discipline: Cancer, Cell Biology
• Test Specificity: Thyroglobulin is a 660kDa dimeric pre-protein with multiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
• Content And Storage: Store at 4°C in the dark.

• Applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin)
• Clone: 2H11 + 6E1
• Dilution: Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin
• Gene Alias: AITD3TGN, TDH3, Tg, thyroglobulin
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Isotype: IgG1 κ