Thyroglobulin Antibody (TGB24), Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP2451230.2MG

Catalog No. NBP24512302

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin)

Thyroglobulin Monoclonal antibody specifically detects Thyroglobulin in Human samples. It is validated for Flow Cytometry, Immunohistochemistry-Paraffin, SDS-Page.

Specifications

• Antigen: Thyroglobulin
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Dilution: Flow Cytometry 0.5 - 1 ug/million cells in 0.1ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, SDS-Page
• Gene Alias: AITD3TGN, TDH3, Tg, thyroglobulin
• Host Species: Mouse
• Molecular Weight of Antigen: 660 kDa
• Quantity: 0.2 mg
• Research Discipline: Cancer, Cell Biology
• Gene ID (Entrez): 7038
• Target Species: Human
• Form: Purified

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page
• Clone: TGB24
• Conjugate: Unconjugated
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Symbols: TG
• Immunogen: Human thyroid follicular cells
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
• Content And Storage: Store at 4C.
• Isotype: IgG1 κ

For Research Use Only