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Thyroid Peroxidase Antibody (TPO/1922) - Azide and BSA Free, Novus Biologicals™
SDP

Catalog No. NB012645 Shop All R&D Systems Products
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100 μg
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NB012645 100 μg
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Catalog No. NB012645 Supplier Novus Biologicals Supplier No. NBP279923
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Description

Mouse Monoclonal Antibody

Thyroid Peroxidase Monoclonal specifically detects Thyroid Peroxidase in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array.

Specifications

Antigen Thyroid Peroxidase
Applications Immunohistochemistry, Immunohistochemistry (Paraffin), Peptide Array
Classification Monoclonal
Clone TPO/1922
Concentration 1 mg/mL
Conjugate Unconjugated
Dilution Immunohistochemistry 1-2 ug/ml, Immunohistochemistry-Paraffin 1-2 ug/ml, Protein Array
Formulation 10 mM PBS with No Preservative
Gene Alias EC 1.11.1, MSA, TDH2A, thyroid microsomal antigen, thyroid peroxidase, thyroperoxidase, TPXEC 1.11.1.8
Gene Symbols TPO
Host Species Mouse
Immunogen Recombinant fragment of human Thyroid Peroxidase (around aa 685-804) (Exact sequence is proprietary) (Uniprot: P07202)
Purification Method Protein A or G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Lipid and Metabolism
Primary or Secondary Primary
Test Specificity Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
Target Species Human
Content And Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1 κ
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