Thyroid Peroxidase Antibody (TPO/1922), HRP, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP279923H

Catalog No. NB012660

Description

Thyroid Peroxidase Monoclonal specifically detects Thyroid Peroxidase in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Thyroid Peroxidase
• Classification: Monoclonal
• Conjugate: HRP
• Formulation: PBS with No Preservative
• Gene Symbols: TPO
• Immunogen: Recombinant fragment of human Thyroid Peroxidase (around aa 685-804) (Exact sequence is proprietary) (Uniprot: P07202)
• Quantity: 0.1 mL
• Research Discipline: Lipid and Metabolism
• Test Specificity: Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
• Content And Storage: Store at 4°C in the dark.

• Applications: Immunohistochemistry, Immunohistochemistry (Paraffin)
• Clone: TPO/1922
• Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin
• Gene Alias: EC 1.11.1, MSA, TDH2A, thyroid microsomal antigen, thyroid peroxidase, thyroperoxidase, TPXEC 1.11.1.8
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Isotype: IgG1 κ