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Invitrogen™ Thyroid Peroxidase Monoclonal Antibody (MoAb47)
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Catalog No. MA125524
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250 μL
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MA125524 250 μL
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Catalog No. MA125524 Supplier Invitrogen™ Supplier No. MA125524
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Description

Mouse Monoclonal Antibody

Recommended positive controls: Thyroid. Perform heat mediated retrieval with 1 mM EDTA buffer, pH 8.0. We suggest incubation period of 30-60 minutes at room temperature.

Thyroid Peroxidase is a gene that encodes for a membrane-bound glycoprotein, which functions as an enzyme and plays a crucial role in the proper functioning of the thyroid gland. This protein is responsible for the iodination of tyrosine residues in thyroglobulin and the formation of phenoxy-ester between pairs of iodinated tyrosines, which leads to the production of thyroid hormones such as thyroxine and triiodothyronine. Mutations in this gene are known to cause several disorders related to thyroid hormone production, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Several transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants remains undetermined. Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Thyroid Peroxidase
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone MoAb47
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Tissue culture supernatant with 0.09% sodium azide
Gene TPO
Gene Accession No. P07202
Gene Alias EC 1.11.1; LOW QUALITY PROTEIN: thyroid peroxidase; MSA; TDH2A; thyroid microsomal antigen; thyroid peroxidase; thyroid peroxidase (332 AA); thyroperoxidase; TPO; TPX; TPXEC 1.11.1.8
Gene Symbols TPO
Host Species Mouse
Immunogen Human thyroid peroxidase (hTPO) purified from thyroid microsomes.
Quantity 250 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7173
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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