Invitrogen™ Thyroid Peroxidase Monoclonal Antibody (MoAb47)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA125524

Catalog No. MA125524

Description

Recommended positive controls: Thyroid. Perform heat mediated retrieval with 1 mM EDTA buffer, pH 8.0. We suggest incubation period of 30-60 minutes at room temperature.

Thyroid Peroxidase is a gene that encodes for a membrane-bound glycoprotein, which functions as an enzyme and plays a crucial role in the proper functioning of the thyroid gland. This protein is responsible for the iodination of tyrosine residues in thyroglobulin and the formation of phenoxy-ester between pairs of iodinated tyrosines, which leads to the production of thyroid hormones such as thyroxine and triiodothyronine. Mutations in this gene are known to cause several disorders related to thyroid hormone production, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Several transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants remains undetermined. Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism.

Specifications

• Antigen: Thyroid Peroxidase
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Tissue culture supernatant with 0.09% sodium azide
• Gene Accession No.: P07202
• Gene Symbols: TPO
• Immunogen: Thyroid Peroxidase purified from human thyroid microsomes.
• Regulatory Status: RUO
• Gene ID (Entrez): 7173
• Content And Storage: 4°C, do not freeze
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Clone: MoAb47
• Conjugate: Unconjugated
• Gene: TPO
• Gene Alias: EC 1.11.1; LOW QUALITY PROTEIN: thyroid peroxidase; MSA; TDH2A; thyroid microsomal antigen; thyroid peroxidase; thyroid peroxidase (332 AA); thyroperoxidase; TPO; TPX; TPXEC 1.11.1.8
• Host Species: Mouse
• Quantity: 250 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov