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Invitrogen™ Thyroid Peroxidase Polyclonal Antibody
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Catalog No. PIPA5103048
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PIPA5103048 100 μL
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Catalog No. PIPA5103048 Supplier Invitrogen™ Supplier No. PA5103048
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total TPO.

Thyroid Peroxidase is a gene that encodes for a membrane-bound glycoprotein, which functions as an enzyme and plays a crucial role in the proper functioning of the thyroid gland. This protein is responsible for the iodination of tyrosine residues in thyroglobulin and the formation of phenoxy-ester between pairs of iodinated tyrosines, which leads to the production of thyroid hormones such as thyroxine and triiodothyronine. Mutations in this gene are known to cause several disorders related to thyroid hormone production, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Several transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants remains undetermined. Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Thyroid Peroxidase
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TPO
Gene Accession No. P07202
Gene Alias EC 1.11.1; LOW QUALITY PROTEIN: thyroid peroxidase; MSA; TDH2A; thyroid microsomal antigen; thyroid peroxidase; thyroid peroxidase (332 AA); thyroperoxidase; TPO; TPX; TPXEC 1.11.1.8
Gene Symbols TPO
Host Species Rabbit
Immunogen A synthesized peptide derived from human TPO(Accession P07202), corresponding to amino acid residues L138-P188.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7173
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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